Vanilla Sky (2001) .... Sofia Serrano
Sin noticias de Dios (2001) .... Evil Angel
... aka No News From God (2001) (USA)
... aka Without News of God (2001) (USA)
America: A Tribute to Heroes (2001) (TV) .... Herself
Captain Corelli's Mandolin (2001) .... Pelagia
... aka Capitaine Corelli (2001) (France)
Blow (2001) .... Mirtha Jung
73rd Annual Academy Awards, The (2001) (TV) (uncredited) .... Presenter of Best Costume Design
All the Pretty Horses (2000) .... Alejandra de la Rocha

Woman on Top (1999) .... Isabella Oliveira
Volavérunt (1999) .... Pepita Tudó
... aka Volavérunt (1999) (France)
Todo sobre mi madre (1999) .... Sister Rosa
... aka All About My Mother (1999) (Europe: English title) (USA)
... aka Tout sur ma mère (1999) (France)
Hi-Lo Country, The (1998) .... Josepha O'Neil
Niña de tus ojos, La (1998) .... Macarena Granada
... aka Girl of Your Dreams, The (1998)
Talk of Angels (1998) .... Pilar
Man with Rain in His Shoes, The (1998) .... Louise
... aka If Only... (1998) (Australia) (France) (UK: video box title)
... aka Lieber gestern als nie (1999) (Germany)
... aka Lluvia en los zapatos (1999) (Spain)
... aka Twice Upon a Yesterday (1999) (USA)
Don Juan (1998) .... Mathurine
Abre los ojos (1997) .... Sofía
... aka Open Your Eyes (1997) (USA)
... aka Ouvre les yeux (1998) (France)
Carne trémula (1997) (as Penelope Cruz) .... Isabel
... aka En chair et en os (1997) (France)
... aka Live Flesh (1997) (USA)
Hjørne af paradis, Et (1997) .... Doña Helena
... aka Corner of Paradise, A (1997) (USA)
... aka Doft av paradiset, En (1999) (Sweden)
Amor perjudica seriamente la salud, El (1996) .... Diana (30 años más joven)
... aka Amour nuit gravement à la santé, L' (1998) (France)
... aka Love Can Seriously Damage Your Health (1996)
... aka Love Causes Serious Harm to Your Health (1996)
Framed (1996) (as Penelope Cruz Sánchez)
Más que amor, frenesí (1996)
... aka Not Love, Just Frenzy (1996)
Celestina, La (1996) .... Melibea
Brujas (1996/I) .... Patricia
Entre rojas (1994) .... Lucía
Todo es mentira (1994) .... Lucía
... aka It's All Lies (1994)
... aka Life's a Bitch (1994)
Alegre ma non troppo (1994) .... Salomé
Per amore, solo per amore (1993) .... Mary
... aka For Love, Only for Love (1993)
Ribelle, La (1993) .... Enza
... aka Rebel, The (1993)
Jamón, jamón (1992) .... Silvia
... aka Ham Ham (1992)
... aka Salami, Salami (1992)
Belle époque (1992) .... Luz
... aka Age of Beauty, The (1992)
Framed (1992) (TV) .... Lola Del Moreno
Laberinto griego, El (1991) .... Elise
... aka Greek Labyrinth, The (1991)
"Quinta Marcha, La" (1990) TV Series .... Host